Retatrutide

Retatrutide (LY3437943) is a high-purity synthetic 39-amino acid polypeptide (>99% purity verified by HPLC and Mass Spectrometry) supplied by Peptide Source exclusively for in-vitro laboratory research, scientific experimentation, and academic purposes. It functions as a triple agonist of glucose-dependent insulinotropic polypeptide (GIP) receptor, glucagon-like peptide-1 (GLP-1) receptor, and glucagon receptor (GCGR), engineered as a single peptide molecule with modifications for enhanced stability and multi-receptor engagement in experimental models.

Chemical and Structural Specifications:

• Sequence: Tyr-{Aib}-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Ile-{α-Me-Leu}-Leu-Asp-Lys-{diacid-C20-gamma-Glu-(AEEA)-Lys}-Ala-Gln-{Aib}-Ala-Phe-Ile-Glu-Tyr-Leu-Leu-Glu-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH₂ (Aib = 2-aminoisobutyric acid; α-Me-Leu = α-methylleucine; lipidated at Lys20 via gamma-Glu and AEEA linker to C20 fatty diacid)
• Molecular Formula: C₂₂₁H₃₄₂N₄₆O₆₈
• Molecular Weight: 4731.33 g/mol
• CAS Number: 2381089-83-2
• Form: Lyophilized (freeze-dried) powder for stability
• Purity: >99% (analytical grade)
• Storage Recommendation: -20°C or lower, protected from light and moisture
• Solubility: Soluble in sterile water or buffers for in vitro use

Retatrutide is derived from a GIP backbone with non-coded residues (Aib at positions 2 and 20, α-methylleucine at 13) and a C20 fatty diacid conjugation for albumin binding and prolonged half-life (~6 days in models). In controlled preclinical and in-vitro research, it is investigated for multi-receptor activation, including cAMP signaling, glucose homeostasis modulation, energy expenditure pathways, and metabolic regulation in cell-based assays or receptor pharmacology systems. The triple agonism enables studies on synergistic incretin/glucagon effects, receptor crosstalk, and downstream metabolic cascades in non-human experimental contexts.

This lipidated structure supports extended exposure in assays, making retatrutide a valuable reagent for exploring incretin mimetics, glucagon receptor dynamics, and multi-hormone signaling in biochemical research.

Critical Compliance and Safety Notice: Peptide Source supplies retatrutide strictly for research laboratory use only (in-vitro experiments, receptor binding studies, cell culture assays, metabolic pathway analysis, etc.). This product is not intended, approved, or safe for human use, consumption, self-administration, therapeutic purposes, metabolic treatment, or any non-research application. It is not for food, drug, cosmetic, or veterinary use. Researchers are responsible for proper handling, storage, and compliance with institutional biosafety protocols and regulations. Peptide Source provides no medical advice and prohibits any misuse. Certificates of Analysis (COA) available upon request for purity, identity, and quality verification.

Peptide Source is a trusted supplier of premium research peptides like retatrutide (LY3437943), with rigorous quality control, secure packaging, and fast worldwide shipping (including Greece). Contact us for bulk options or documentation.