CJC-1295 DAC 5mg

CJC-1295 DAC (CJC-1295 with Drug Affinity Complex) is a high-purity synthetic peptide analog of growth hormone-releasing hormone (GHRH) (>99% purity verified by HPLC and Mass Spectrometry) supplied by Peptide Source exclusively for in-vitro laboratory research, scientific experimentation, and academic purposes. It is a modified version of GRF (1-29) with strategic amino acid substitutions for enhanced stability and the addition of a Drug Affinity Complex (DAC) moiety, which promotes binding to serum albumin to extend its pharmacokinetic half-life significantly compared to non-DAC variants.

Chemical and Structural Specifications:

• Sequence: Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Leu-Ser-Arg (with Lys substitutions at positions like 8,15,27 and DAC attached via maleimidopropionyl-Lys at C-terminus; often abbreviated YADAXFXQSYRKVLAQLSARKLLQDXLSR where X = modified residues)
• Molecular Formula: C₁₆₅H₂₆₉N₄₇O₄₆ (approximate for DAC form)
• Molecular Weight: 3647.19–3647.28 g/mol
• CAS Number: 446262-90-4
• Form: Lyophilized (freeze-dried) white powder
• Purity: >99% (analytical grade)
• Storage Recommendation: -20°C or lower, protected from light and moisture
• Solubility: Soluble in sterile water or buffers for in vitro use

CJC-1295 DAC features four key amino acid modifications in the base GRF(1-29) sequence (e.g., D-Ala at position 2 for DPP-4 resistance, substitutions at 8/15/27 for stability and bioactivity) plus the DAC group (N-epsilon-maleimidopropionamide-Lys linker), which enables prolonged albumin binding and a half-life of approximately 6–8 days in research models. In controlled preclinical and in-vitro studies, it is used to investigate sustained stimulation of endogenous growth hormone (GH) release from pituitary somatotrophs, GH/IGF-1 axis dynamics, pulsatile vs. continuous signaling patterns, and related endocrine pathways in non-human experimental systems. The DAC extension allows researchers to model long-term GHRH analog effects without frequent dosing in assays.

Unlike CJC-1295 without DAC (shorter half-life ~30 minutes, more pulsatile GH release), the DAC version provides extended exposure, making it suitable for studies requiring prolonged GH elevation in cell culture, receptor pharmacology, or animal models.

Critical Compliance and Safety Notice: Peptide Source supplies CJC-1295 DAC strictly for research laboratory use only (in-vitro experiments, biochemical assays, receptor binding studies, endocrine pathway analysis, etc.). This product is not intended, approved, or safe for human use, consumption, self-administration, performance enhancement, anti-aging, therapeutic purposes, or any non-research application. It is not for food, drug, cosmetic, or veterinary use. Researchers must adhere to institutional biosafety protocols, safety guidelines, and local regulations. Peptide Source provides no medical advice and prohibits misuse. Certificates of Analysis (COA) are available upon request for purity, identity, and quality verification.

Peptide Source is a trusted supplier of premium research peptides like CJC-1295 DAC, with rigorous quality control, secure packaging, and fast worldwide shipping (including Greece). Contact us for bulk inquiries or additional documentation.